His words are meaningless.

His talk was completely nonsense.

This discussion is completely meaningless.

His meaningful gaze made me uneasy.

He is majoring in semantics at university.

His words were profound, which made me think.

The story of the loyal retainers of Akō Domain is deeply engraved in Japanese history.

Gisaburo is my best friend.

She is so slender that she seems to be nothing but skin and bones.

She was so slender to the point of being bony, she didn't look healthy.