気にする: mind something

(idiomatic) to care about something, to pay undue attention to something, to mind something which is a negative nuance, to worry about something

大きに: (Kansai, Hokuriku) thank you

大事に: importantly, seriously

to be so intoxicated as to be out of control; drunk

何事: what sort of matter; unspecified matter

勝手に: selfishly; for one's convenience; wilfully, as one pleases

古: the past; ancient times

気になる: to care about, to worry about

(idiomatic) to cause concern, to be worrisome, to be on one's mind / to be interested, to be curious