to ascend and descend, to climb and come back down (particularly as of a person or thing travelling or moving up and down, such as stairs or levels)

climbing up and climbing down (particularly as of a person or path travelling or moving up and down, such as a road going uphill and downhill in the mountains)

to climb up and climb down / to go upstream and downstream (such as on a river, or on a highway with “up” indicating towards a city)

in kambun, a tertiary type of kaeriten following ichiniten and kōotsuiten in which the reading order is marked with 上, 中, and 下 indicating the order

up and down, left and right

there is no lower/upper distinction in love: "love is blind"