(sumo) an overhand hold / (sumo) the upper hand in an overhand hold / upstream, the upstream portion of a river / upwind / a skilled player of games, such as go or shogi

upstream, the upstream portion of a river / upwind / uphill, the upper portion of a hill or other geographic feature / the head of a table, the seat of honor

(rare) the left-hand side of a drawstring on a fishing net

skillful, dexterous

good at

(chiefly women's speech) first person singular pronoun: I, me

(polite) first-person singular pronoun: I, me

a personal or private matter / (by extension) selfishness

(formal) first-person singular pronoun: I, me

personal, private / secret