(intransitive, idiomatic, slang, vulgar) To perform oral sex on another person.

(transitive) To surrender (someone or something) / (transitive) To stop or quit (an activity, etc.) / (transitive) To relinquish (something) / (transitive) To lose hope concerning (someone or something)

(colloquial) What is wrong? Why is this happening? / (colloquial, possibly dated) What is happening? What is going on? / (colloquial) How are you?

(idiomatic, intransitive) To chase or pursue a person.

(idiomatic) To give somebody cause for concern.

(transitive) To make a gift of (something). / (transitive) To relinquish control over. / (transitive) To formally hand over a bride to the bridegroom; often by her father.

(vulgar, chiefly in negative constructions) To care what someone else thinks or does, particularly in relation to what they think or say about the speaker.

(usually transitive) To make an obscene gesture (towards someone) by closing the fist and extending the middle finger upwards.

Used other than figuratively or idiomatically: see give, notice. / (idiomatic) To announce one's intent to leave a job; to inform an employer that one is leaving.

(idiomatic, vulgar, chiefly in the negative) To care; to give a shit.