(colloquial) What is good, especially in reference to food. / (slang) What's up? a casual greeting

For what purpose, what for, why

(idiomatic) What is wrong with...? What is the problem with... (somebody)? Inquired regarding somebody who seems upset, worried, angry, etc.

(slang) Alternative form of what's up

(idiomatic, colloquial) What did you say?; Huh?; expresses incredulity.

Considering what limited worth this advice, opinion, or suggestion might have for you; used to soften the presentation of unsolicited advice or information that may not be relevant.

(followed by a phrase) Regardless, in spite of. / (not followed by a phrase) Regardless of any or most possible adverse circumstances.

(defensively) Why are you asking? Why do you want to know?. / Mind your own business; it's none of your business.

(US) A shop selling miscellanea.

(African-American Vernacular) What's up? What's going on?