(informal) To complain; to demand attention or remedy for a problem.

(US) Americanized form of in for a penny, in for a pound.

(idiomatic) To create a predicament or problem for oneself; to do something that leaves one with no good alternatives or solutions.

(Ireland) Those who fail to speak up fail to get what they want.

Likely to happen only once in one's lifetime.

(derogatory, minced oath) Asshole, arsehole.

(idiomatic, informal) Very angry.

(chiefly US, colloquial, idiomatic, somewhat vulgar) To be manly, brave.

(law) To allege a place.

(idiomatic, humorous, informal) Synonym of get one's knickers in a twist