A request for clarification of what the listener just said.

A rhetorical question asked to show that the person asking it neither knows the answer nor would be able to know it.

(idiomatic, dated) A phrase used at parting.

(colloquial) A greeting, asking about a person's life; how are you?

(slang, obsolete) Drunk.

(humorous, emphatic) Synonym of how dare you

Used to ask someone for their opinion. / (humorous, derogatory) Used to deride the character or personality of someone.

Alternative form of how do you like them apples

(idiomatic, chiefly in the negative) To tell an expert how to do things.

A rhetorical question, used to tell someone that they should feel guilty about something.