when walking or running, to reach a full or comfortable pace / (figuratively) to reach a full level of efficiency, competence, comfort, etc.; to get going

Alternative form of one-upmanship

Used other than figuratively or idiomatically: see hold, one's, breath. To keep air in one's lungs, pausing noticeably before exhaling after previously inhaling.

(idiomatic) To solve two problems with one single action.

(idiomatic, of an idea) To occur to somebody; to be realized.

(idiomatic) To monitor; to keep track of; to watch.

(figuratively) To regret or retract what one has said.

(US, idiomatic) To outdo oneself or do more than one's previous best.

(Britain, slang) To commit suicide.

Alternative spelling of on the up-and-up