(slang, humorous) An antidepressant.

A diuretic in pill form.

A placebo medication made with sugar. / Used other than figuratively or idiomatically: see sugar, pill.

plural of pill mill

(idiomatic) A clandestine operation where a medical worker illicitly offers prescription medication to patients in exchange for bribes.

(informal) Any drug used to promote wakefulness, such as amphetamine.

(colloquial) An elevated neighborhood where there is a hospital or a large concentration of doctors' homes or offices.

(colloquial, often in imperative) To change one's attitude or expressed feeling.

Used other than figuratively or idiomatically: see pill, swallow. / Something to be accepted or tolerated.

(idiomatic, sometimes mildly humorous) A medicinal pill which is very large in size and is therefore difficult for a person to swallow.