(idiomatic) To have no common sense; to be ignorant of the most basic facts; to be very confused.

plural of two-up-two-down

(UK) A traditional house with two rooms upstairs and two rooms downstairs.

(idiomatic, with "at") Alternative form of turn up one's nose

(informal, sarcastic) Said to prompt the interlocutor to stop looking lustfully at the speaker's body.

(idiomatic) To become enthusiastic about something that is not yet guaranteed to happen.

(informal, used imperatively) get a grip

Alternative form of know which end is up

(idiomatic) To possess sound judgment or common sense; to have a clear understanding of a situation.

(figuratively) To annoy or anger someone.