(figuratively) To be killed, usually in a gruesome manner. / (literally) To suffer decapitation.

(idiomatic) To lose all of one's money; to go broke; to undergo financial ruin or disaster.

To have sexual intercourse for the first time.

(slang) To vomit, throw up.

(intransitive, idiomatic) To become angry or annoyed.

(idiomatic) To become frustrated, angry. / (idiomatic) To become crazy, insane.

(idiomatic) To lose one's special mastery of or knack for a particular skill or activity.

(idiomatic, vulgar) To lose one's temper. / (idiomatic, vulgar) To have a sudden burst of emotion, regardless of the type of feeling. / (idiomatic, vulgar) To break down in laughter.

(idiomatic) To become upset or disconcerted; to lose one's temper.

To become lost; to lose one's bearings, or idea of where one is. / (figuratively) To cease to succeed or to follow the right path; to fail.