(mildly vulgar, slang) An intensive form of what. / (mildly vulgar, slang) Indicating acceptance, indulgence, or insouciance: Why not? Who cares?

(colloquial, rhetorical question, impolite) A reply to an unimportant or irrelevant statement, indicating indifference on the part of the speaker.

(euphemistic) what the hell

For what purpose, what for, why

(slang) Alternative form of what's up

(idiomatic, colloquial) What did you say?; Huh?; expresses incredulity.

Considering what limited worth this advice, opinion, or suggestion might have for you; used to soften the presentation of unsolicited advice or information that may not be relevant.

(followed by a phrase) Regardless, in spite of. / (not followed by a phrase) Regardless of any or most possible adverse circumstances.

(US) A shop selling miscellanea.

(African-American Vernacular) What's up? What's going on?