(idiomatic) To initiate contact or a relationship; to gain access, especially to an entry-level job.

Whoever arrives first has the best chance of success; some opportunities are only available to the first competitors.

(idiomatic) To annoy or anger someone.

(simile) To immediately start a good relationship with someone.

(idiomatic) To become serious, organized, worthwhile, etc.

(idiomatic) To experience the consequences of one's actions.

(idiomatic) To be unable to say a single word because of someone else's talkativeness.

(idiomatic, chiefly US) To deal with the important details.

(informal, transitive, intransitive) To cease pestering or criticizing someone, i.e. to leave them alone.

(vulgar, idiomatic, imperative) Act now or state one's disinterest, make a decision, particularly in contexts where one is inconveniencing others by inaction and indecision.