(Canada) The office of Prime Minister of Canada.

The presence of three copies of the 21st chromosome in the karyotype.

(idiomatic, archaic, chiefly US) To leave, particularly quickly or at an advantageous time. / (idiomatic, archaic, chiefly US) To be forced to leave quickly.

(idiomatic, dated, rare, chiefly US) A fictitious place or a generic place that could refer to any location.

Former name of 24 Sussex Drive.

The decade from 2010 to 2019.

The decade from 2020 to 2029.

(postpositive) A second major version of something or, figuratively, of someone; a substantial improvement.

Abbreviation of twenty-twenty.

(humorous) A phrase indicating that something must be done directly without delays or deviations.