(business, derogatory) Large, prosperous pharmaceutical firms collectively, understood as a business group having significant economic, political, or social influence.

Alternative form of big pharma

A heavy, long-range howitzer used by Germany in World War I.

plural of big deal

(idiomatic) One who frequently makes large purchases, especially of extravagant goods.

A major player in the field in question: someone who is in the big time

(attributive) Alternative spelling of big tent

A major league.

Major league (pertaining to the highest level of professional sports). / Major league (significant, important).

(slang) To a significant degree; on a large scale.