large but not obese / (humorous or euphemistic) Fat, obese.

(countable) A large dance or jazz band of 10 to 30 musicians usually featuring improvised solos by lead players, but otherwise playing orchestrated music.

plural of big band

(informal) The computer company IBM.

(business, derogatory) Large, prosperous pharmaceutical firms collectively, understood as a business group having significant economic, political, or social influence.

Alternative form of big pharma

A heavy, long-range howitzer used by Germany in World War I.

plural of big deal

(idiomatic) One who frequently makes large purchases, especially of extravagant goods.

A major player in the field in question: someone who is in the big time