She may not be conventionally attractive, but she has a great sense of humor and a kind heart. She's esthetically challenged, but that's what makes her unique.

She is aurally challenged and relies on sign language to communicate.

I may be gravitationally challenged, but I can still dance!

He is ethically challenged when it comes to following rules.

She is vertically-challenged and needs a stool to reach the top shelf.

She is vehicularly challenged and relies on public transportation.

Challenger Deep is the deepest point in the Mariana Trench.

He is racially challenged.

She is an employmentally challenged individual.

He is intellectually challenged but he excels in other areas.