He was mad as a box of frogs.

She was mad as a meat axe when she found out she had been lied to.

He was stark staring mad when he found out he lost his job.

The Mad Hatter syndrome is a neurological disorder caused by mercury poisoning.

The mad hatter disease is a neurological disorder caused by exposure to mercury.

There is a method to one's madness.

She was mad as a wet hen when she found out her car had been towed.

His constant complaining drives me mad.

Her constant nagging drove him mad.

Her constant complaining has driven me mad.