(idiomatic, colloquial) Used to express frustration, exasperation, or annoyance.

(idiomatic) retire, call it a day

plural of fact of life / (euphemistic) knowledge of sexual reproduction (almost always used with the)

Something that cannot be avoided.

(idiomatic) Something of particular interest or concern; an obsession.

(idiomatic) To concern oneself only with what is of interest to oneself and not interfere in the affairs of others.

(idiomatic) To find, obtain or procure. / (idiomatic) To seize or assault. / Used other than figuratively or idiomatically: see lay, hands.

To go forward. / To convey or communicate. / To transfer (something) to someone, especially by handing or bequeathing it to the next person in a series. / To skip or decline.

(idiomatic, transitive, intransitive) To stop paying attention to; to ignore; to zone out. / To change the channel or frequency away from.

(informal) To fight, especially with the fists. / (informal) To argue heavily or at length.