(UK, vulgar, slang) To annoy or irritate.

Having only one hand. / Performed using only one hand. / Designed for use with one hand / (specifically, of reading or reading material) Pornographic in nature. / That uses one hand.

Using only one hand; one-handedly. / (figuratively) Very easily, without effort.

(idiomatic) About to die. / (idiomatic, by extension) About to lose viability or become defunct.

(US, idiomatic) To draw one's handgun, especially for an armed confrontation.

(idiomatic) To behave in an offensive, burdensome, or tiresome manner, with the result that one's continued presence is unwanted within a residence, commercial establishment, or social group.

present participle of die on the vine

(idiomatic) To fail at an early stage or never come to fruition, typically due to neglect, infeasibility, or lack of resources. / Used other than figuratively or idiomatically: see die, on, the, vine.

(idiomatic) proudly, with pride

simple past tense and past participle of die on the vine