(idiomatic, transitive) To spend a lot of time doing things for another person or group of people. Often used when that person could reasonably do the things for themselves.

(idiomatic) To alternate between two opposite extremes, such as enthusiasm and disinterest or success and failure.

(originally US, idiomatic) To exhaust; to demand excessive effort or work from somebody.

(transitive) To begin to encounter problems with (someone or something).

(baseball) To hit a ball during an at-bat that results in all runners on base and the hitter scoring runs; the best result of an at-bat. / (figuratively) To achieve the best possible result.

present participle of run up against

Synonym of ride roughshod over

(idiomatic) To demonstrate superiority, or greater skill than another person, team or group of people.

alternative form of run rings around

(idiomatic) To talk excessively. / (idiomatic, derogatory) To speak in a disrespectful manner about somebody.