The extent to which something matters; importance / Meaning.

In a significant manner or to a significant extent.

A courtesy title for an unmarried woman of Italian origin. / (US) maitake, hen of the woods (mushroom)

Mrs; madam; title of address or respect for women in Italy.

To create a sign out of something. / To give (something) a meaning or an importance. / To show one’s intentions with a sign etc.; to indicate, announce. / To mean; to betoken.

(uncountable) Signs, particularly those imparting commercial, directional, or road traffic information, taken collectively.

(computer science) The byte of a multibyte number with the least importance: that is, the byte stored last on a big-endian system or first on a little-endian system.

One who signs or has signed something.

Relating to a seal; used in sealing. / Signing; joining or sharing in a signature.

a visible, audible, mechanical, or electronic signal used as a reference to determine the time of day