He is taking it up the ass.

I am taking out the trash.

She is taking it upon herself to organize the event.

She is taking upon herself the responsibility of organizing the event.

She is taking up the mantle of leadership in the company.

She is taking up the mantle of leadership in the company.

She is taking away from his happiness.

She is taking it to the next level with her new business venture.

I am taking out an onion from the fridge.

She is taking someone to the grave.