(of a drug, etc.) To become active; to become effective. / (of a law, etc.) To come into force, to come into effect, to inure.

(idiomatic) To discourage someone greatly; to cause someone to lose hope or the will to continue; to thwart or minimize someone's ambitions.

(transitive, chiefly in the negative) To tolerate, accept, or acquiesce; to take no action.

(idiomatic) To affect, especially negatively; to damage or degrade; to cause destruction.

(idiomatic, Britain) To be particularly bad, objectionable, or egregious. / (idiomatic, Canada) To be of no further use; to be near death.

(idiomatic) To ally oneself with a given opinion, agenda or group; to support one side or viewpoint in a competition or confrontation.

present participle of take the piss

(vulgar, UK, Australia, New Zealand, slang) An instance of taking the piss. / (vulgar, UK, Australia, New Zealand, slang) A parody.

Alternative form of take the piss

To go hiking. / (idiomatic, often imperative) To go away; to leave or depart.