(idiomatic, intransitive, derogatory) To begin having a more interesting, eventful, or worthwhile existence.

(idiomatic) To squint very much, as though one's eyes were directed as many ways as the points of a bag of nails.

(simile, colloquial) The idea/proposed action is inconsequential to the current situation.

(simile, slang, vulgar) Very drunk.

(idiomatic, obsolete, slang, Britain) A roundabout, nonsensical story.

(American spelling, idiomatic) An unrelated or only incidentally related matter with distinctly different significance.

(Britain, idiomatic, transitive) To do badly; to make a mess of.

(of a hit record) That has entered the charts in a high position, or has climbed rapidly in the charts, or is thought to have the potential for further rapid advancement.

(idiomatic) Superlative; impossible to beat.

Alternative form of up the creek