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sickle cell anaemia
noun
(pathology,
Britain)
A
severe
hereditary
form
of
anaemia,
mainly
affecting
people
of
African
origin,
in
which
mutated
haemoglobin
distorts
red
blood
cells
into
a
crescent
shape,
causing
the
cells
to
become
stuck
in
capillaries.
Downstream
tissues
are
thus
deprived
of
oxygen
causing
ischaemia
and
infarction.
sickle-cell anaemia
refractory anaemia with excess blasts
noun