Characterised by despair; hopeless.

plural of despairing

To distress oneself by comparing one's own situation with that of others who seem more successful.

Depression caused by fear of climate change.

plural of pit of despair

A feeling of utter dread and that there is absolutely nothing that can be done to improve the situation.

A behavior-related medical condition among those who experience despair, caused by the feeling that their long-term social or economic outlook is bleak.

Death resulting from a disease of despair.

plural of disease of despair