She couldn't hide her desponding after receiving the rejection letter.

She desponded after receiving the rejection letter.

She looked despondently out the window, wondering when things would get better.

The desponders gathered together to share their struggles.

The despondences of the students were evident in their low morale.

The despondings of the students were evident in their low energy and lack of motivation.

The hiker got stuck in a slough of despond.

The pilgrims were trapped in the sloughs of despond.