A great or insurmountable difference.

(originally African-American Vernacular, idiomatic, slang) Able to do things which others cannot; extremely talented or unusual. / Used other than figuratively or idiomatically: see built, different.

(African-American Vernacular, Internet slang, intransitive) To be extraordinary.

(American spelling, idiomatic) An unrelated or only incidentally related matter with distinctly different significance.

(algebra) The identity x²-y²=(x+y)(x-y), that holds for all real numbers.

(set phrase) A linguistic or conceptual distinction which is of no practical importance or which has no effect on meaning; a perceived difference where there is no actual difference.

(set theory, of two sets A and B) The set that contains exactly those elements belonging to A but not to B; the relative complement of B in A.

(British spelling) Alternative form of horse of a different color

Alternative form of march to the beat of a different drum

Alternative form of march to the beat of a different drum