Large, wide-open (purportedly innocent-looking) eyes / Large seductive eyes, usually on a woman.

(US, law, law enforcement) A Latina who is unknown, a Jane Doe of Latin descent.

(US, law, law enforcement) A Latino male who is unknown, a John Doe of Latin descent.

A village in Ault Hucknall parish, Bolsover district, Derbyshire, England (OS grid ref SK4666). / A minor river, the River Doe Lea in Derbyshire, which joins the South Yorkshire Rother.

(colloquial, rhetorical question, mildly vulgar) A rhetorical question in response to a question to which the answer is an emphatic yes.

What is its price? How much money do you want for it?

Alternative form of it's not the whistle that pulls the train

(US, dated, colloquial, rhetorical question) A rhetorical question with the implied answer being that competitors do not share business secrets with one another.

Used to ask where the train is going.

Used to ask where the bus is going.