A downward trend, or the beginnings of one; a decline.

To turn downwards / To decline

The portion of any movement along an arc or curve, heading in a lower direction.

(transitive) To make a ruler lose their position of power. / (transitive) To reduce. / (transitive) To humble.

In the horizontal direction away from the launch site of a rocket or projectile in the direction of its travel.

In the horizontal direction away from the launch site of a rocket or projectile in the direction of its travel.

To remove something from a wall or similar vertical surface to which it is fixed. / To remove something from a hanging position. / To remove something from a website.

Alternative spelling of downregulation

(chiefly US) Simple and unpretentious, especially having the characteristics of a Southern rural lifestyle.

(music) The accented beat at the beginning of a bar (indicated by a conductor with a downward stroke).