(idiomatic) To lose all of one's money; to go broke; to undergo financial ruin or disaster.

To have sexual intercourse for the first time.

(slang) To vomit, throw up.

To continue to wage war when it is clear that one is not going to win. / (idiomatic) To try to do something so difficult that it will probably end in failure.

(intransitive, idiomatic) To become angry or annoyed.

(idiomatic) To become frustrated, angry. / (idiomatic) To become crazy, insane.

(idiomatic) To lose one's special mastery of or knack for a particular skill or activity.

(idiomatic, vulgar) To lose one's temper. / (idiomatic, vulgar) To have a sudden burst of emotion, regardless of the type of feeling. / (idiomatic, vulgar) To break down in laughter.

(idiomatic) To become upset or disconcerted; to lose one's temper.

To become lost; to lose one's bearings, or idea of where one is. / (figuratively) To cease to succeed or to follow the right path; to fail.