(idiomatic) Something failed, often after or amidst a laborious, tiring process.

(idiomatic) With a large amount of effort or intensity.

(slang) An act of masturbation.

(idiomatic, slang) Heavily intoxicated; under the influence of alcohol or drugs.

(idiomatic) Indicates that a future event appears uncertain, especially one that before seemed more certain. Any prior agreements are no longer valid.

(idiomatic, transitive) To misguide.

Used other than figuratively or idiomatically: see off, meds. / Out of control.

(idiomatic, sports) fast to act or react

The temperature at which catalytic reactions are initiated within a catalytic converter.

(idiomatic, baseball) for a pitcher to throw a pitch at or near the batter, typically to frighten the batter or to have him stand farther away from home plate.