Needing only a single attempt to become effective. / Unique; occurring only once. / Performing all the necessary steps on every occurrence, rather than relying on previous setup.

(television, film, comics) A television program, film, or comic book that is not part of a series. / (film) A cinematographic shot of a person talking to camera; a talking head.

(video games) To kill or destroy with a single hit.

Misspelling of one-legged.

(colloquial, figuratively) One's sanity; one's mental faculties.

formerly / simultaneously, at once.

During sequentially discrete instances.

(colloquial) An exclamation of praise or encouragement.

A member of the top one percent of a population by wealth, ability, etc. (same as the ninety-ninth percentile), especially in a society with high wealth inequality.

plural of one under