(idiomatic) To start making an effort; to renew or redouble one's efforts.

(intransitive, idiomatic) To proceed with the matter in hand.

(chiefly Britain, idiomatic) To remain cheerful; keep smiling.

(idiomatic) To initiate contact or a relationship; to gain access, especially to an entry-level job.

In earnest; sincerely; with one's full feeling.

(idiomatic, intransitive) To be crazy or eccentric.

(idiomatic) To raise one's clenched fists in front of one's body and stand in a threatening or defiant manner, in preparation for a fistfight.

(idiomatic) To create a difficult situation whose unpleasant consequences one must now endure.

(idiomatic) To make an extra effort, so as to help or hinder.

(idiomatic) To become serious, organized, worthwhile, etc.