(idiomatic) To maintain one's concentration fixed on one important theme.

(idiomatic) To work especially hard, usually for an extended period.

(idiomatic) To be dismissed disgracefully

(idiomatic) To take a risk, putting oneself in a vulnerable position.

(simile) Extremely evident and plain to see.

(figuratively or symbolically) To go on strike.

(idiomatic) To behave toward others in a manner resembling or commensurate with their behavior towards oneself, especially in a situation where one is insulted or otherwise ill-treated.

(Britain, informal) Used as a fatuous excuse to avoid doing something.

(idiomatic) To exercise influence or authority, especially to an excessive degree or in an objectionable manner.

(idiomatic) To go crazy; to stop behaving rationally.