A style of architecture, furniture, etc. popular during the reign of Queen Anne. / (attributive) Designating the style of architecture, furniture, etc. popular during the reign of Queen Anne.

Queen Anne of Great Britain (reigned 1702–1714). / A small town in Maryland, United States.

(US) In colleges and high schools, a young lady chosen by her peers to "reign" over the traditional activities associated with the Homecoming football game.

(idiomatic, slang, originally LGBT, sometimes derogatory) Someone who prefers sexual partners with large penises.

(LGBT, originally slang) A person, usually male, who dresses up in women’s clothing and makeup, typically in an exaggerated fashion and for public performance.

(slang) A female speedfreak; a woman who abuses stimulating drugs.

A reproductive female (especially the only one) in a colony of bees. / (idiomatic, colloquial, derogatory) The most important or dominant woman in an organisation or situation. / (metaphoric) Stem cell

Pertaining to a larger-than-average dress, blouse, skirt, pant or stocking size for women.

(idiomatic, informal, derogatory) An overly or exaggeratedly dramatic person.

(informal, intransitive, uncommon) To behave in an exaggerately dramatic fashion.