To make the gesture of raising one's nose, as a sign of scorn, contempt or disgust.

(idiomatic) To relax.

(idiomatic) To have become very frustrated or angry; to have reached the limit of one's patience or forbearance.

(idiomatic) To reform; to improve one's habits.

To come to an accounting; to examine and strike the balance of debt and credit; reckon. / (idiomatic, archaic) To vomit.

Alternative form of up the creek

(idiomatic) To do, believe, or pursue something wrong or inappropriate; to take the wrong approach; to follow a false lead; to blame or rebuke the wrong person.

(idiomatic) To decide; to reach a conclusion.

(idiomatic) retire, call it a day

(idiomatic) To start making an effort; to renew or redouble one's efforts.