(US, informal) What is wrong with X? What's X's problem? Is X crazy?

What is the time of day? (used to request for the current hour and approximate number of minutes after the hour)

(idiomatic, colloquial) An intensified version of what? or huh?, expressing surprise or lack of comprehension

Used to make a suggestion. / Used to ask someone to consider something or someone that they have apparently not considered. / To repeat a question but referring to a different subject or object.

(idiomatic, Britain, colloquial) An intensified version of what or huh.

(interrogative, vulgar, slang) An intensive form of what.

(vulgar) Used to express astonishment, shock, incredulity, or disbelief (as a shortened form of expressions such as "What the fuck is going on?", "...are you doing?", "…is this?" "…is it" or "...is that?").

(colloquial) What is wrong? Why is this happening? / (colloquial, possibly dated) What is happening? What is going on? / (colloquial) How are you?

(idiomatic) furthermore, or in addition, moreover.

(euphemistic) what the hell