A request, usually rhetorical, to know what, in a series of negative events, is the next negative event occurring.

(idiomatic, rhetorical question) Why are you complaining? What are you complaining about?

Alternative form of what's the good of

Said by one friend to another in response to thank you.

Used to express regret or disappointment about an unfortunate event or piece of information.

(archaic) But what does it matter; notwithstanding.

(archaic, colloquial) Of what kind.

Alternative form of what the eff.

Alternative form of what next

Used to express surprise or amazement.