(LGBT, originally slang) A person, usually male, who dresses up in women’s clothing and makeup, typically in an exaggerated fashion and for public performance.

simple past tense and past participle of irk

(also figuratively) To rub or wear away (something); to cause (something made of strands twisted or woven together, such as cloth or rope) to unravel through friction; also, to irritate (something)...

(chemistry, military) The nerve gas O-pinacolyl methylphosphonofluoridate, used as a chemical weapon.