An increasing quantity of evidence supports a force-driven mode of activation of the Notch signalling pathway, whereby exposure of the critical S2 site in the Notch NRR occurs upon mechanical unfolding of the protein during transendocytosis of the Notch extracellular domain into the ligand presenting cell.

Considering the supposed losses due to camming, the small reward and associated limitations on receiving it are unlikely to encourage employees to make the extra, and perhaps dangerous, effort to stop this illegal conduct.

Backwards, it spreads to the beginningless beginning. Forwards, it spreads to the endless end. We are always in the middle.

I shall go to Japan and hence will not be here in time for the party.