Online child sex abuse has increased by 27 per cent in just two years, as the NSPCC called for tougher laws to combat “digital breadcrumbing” that signposts paedophiles to illegal content.

Chitta (Diacetymorphine, a semisynthetic opioid), is an adulterated form of heroine and is addictive.

Now mayſter (ꝙ the wyfe) er that I go / What wol ye dyne? I wol go ther aboute. Now master, (quod the wife), ere that I go, / What will ye dine? I will go thereabout.]

However, there were five known druggable targets that had scored in the 'undruggable' target range.