[I]chores and thoſe ſerious matters being thickned become flegme, and flegme degenerates into choler, choler aduſt becomes æruginoſa melancholia, as vinegar out of the pureſt wine putrified or by exhalation of purer ſpirits is ſo made, and becomes ſowre and ſharp; […]