Although developed as antiresorptive agents, several compounds show lysosomotropic effects, cutaneous adverse effects and anabolic activity, which are intrinsically related to the selectivity of inhibitors toward CatK. Therefore, alternative compounds having better selectivity toward CatK may complement the use of CKIs in bone resorption therapy.

Lieutenant Frog's rich frogly voice / Husky grew with his great theme;

The expressive power of intonation in communication with preverbal infants was a topic of considerable interest in the early literature on language acquisition.

South of the North American coign we have again a pair of east - west mountain chains