最終更新日:2022/12/24
An exciting recent advance in the vanilloid field has been our discovery that resiniferatoxin (RTX), a naturally occurring diterpene combining structural features of the phorbol ester tumor promoters and of capsaicin (see structures in Fig. 1), functions as an ultrapotent capsaicin analog (4—6) and that the esterification of other phorbol-related diterpenes with homovanillic acid at the C-20 position yields synthetic vanilloids of the RTX class with unique spectra of action (7).
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An
exciting
recent
advance
in
the
vanilloid
field
has
been
our
discovery
that
resiniferatoxin
(RTX),
a
naturally
occurring
diterpene
combining
structural
features
of
the
phorbol
ester
tumor
promoters
and
of
capsaicin
(see
structures
in
Fig.
1),
functions
as
an
ultrapotent
capsaicin
analog
(4—6)
and
that
the
esterification
of
other
phorbol-related
diterpenes
with
homovanillic
acid
at
the
C-20
position
yields
synthetic
vanilloids
of
the
RTX
class
with
unique
spectra
of
action
(7).