Since 1935 when Domagk demonstrated that prontosil provided effective therapy in a murine pneumococcal infection model, the use of animal infection models has become an integral part of the evaluation of new antimicrobial agents and new therapeutic approaches for clinical trials in humans.

three-fifths qualified majority

Orlando, it is true, was none of those who tread lightly the coranto and lavolta; he was clumsy; and a little absent-minded.

Their crowned truths