Among the companies that have had setbacks or outright failures in clinical trials are Roche and Biogen Idec with their drug Rituxan; La Jolla Pharmaceutical with Riquent; Bristol-Myers Squibb with Orencia; ZymoGenetics and Merck Serono with atacicept; Genelabs Technologies with Prestara; Teva Pharmaceutical Industries with edratide; and Aspreva Pharmaceuticals and Roche with CellCept.