However, in doing so, the principle of equipoise—recognized by many as the primary ethical justification for an RCT, any RCT—loses some of its force. You might still find it, but the emphasis is elsewhere: on social value, on scientific validity, on independent review, on respect, on informed consent. Important values all, but by deconflating research from treatment, investigators are relieved from the constraints of the personal-care principle and the absolute prohibition against doing harm. The deconflation has defeated equipoise.

In the hey-day of youth, and hardly out of the leading strings of a school, he formed an intention to nuptialize, and joined heart and hand with sweet Ann Hathaway at the age of eighteen and a half.

As the mysteries of valetism are not very recondite or difficult to be acquired by an intelligent person, Lockwood, after a little practice, performed his functions handily enough; […]

This system of penalties shall equally apply to the winners of scratch events, and to the winning of holderships of trophies, but not to the winner of rounds in the C.B.S.A. medal competitions.